Society of toxicology

Metabolic syndrome is defined by a combination of risk factors that can lead to greater potential of type 2 diabetes, obesity, lipid disorders, cardiovascular disease, and other circulatory disorders. Low carb diet bad breath There is currently a significant research focus to understand the key pathways that control metabolism, as these pathways would be likely targets of risk factors (e.g., exposure to xenobiotics, genetics) and lifestyle factors (e.g., microbiome, nutrition, and exercise). Losing weight over 60 Understanding these pathways also can lead to the development of pharmaceutical interventions. Exercises to burn fat and build muscle Individuals with metabolic syndrome have signs similar to that of toxic responses (e.g., oxidative stress and inflammation) and organ dysfunction. Exercise tiger 1944 Given the rapidly growing incidence of this syndrome, it is critical to understand these widespread abnormalities as it changes our definition of “normal.” This syndrome can be driven by fat accumulation around intra-abdominal sites (possibly driven by genetic and epigenetic factors leading to predisposition of retaining fat at this site due to poor intra-uterine growth), organ impairment (e.g., non-alcoholic fatty liver disease), and exposure to xenobiotics. Paleo indians While the causes for escalation in the individual risk factors are multiple and complex, there is no clear recognition of the bridges that unite these risk factors to yield increased disease. Exercise unlimited Indeed, it is likely that there are pathways that are of importance to controlling metabolism that would be targets of both environmental chemicals and pharmaceutical interventions. Weight loss calendar countdown A multidisciplinary approach to understand the underlying biological mechanisms and translate that knowledge into prevention and treatment is required.

This conference will examine, in the morning, current knowledge on metabolic diseases including developmental aspects and challenges in therapeutic strategies for associated diseases. Cinnamon and weight loss recipe A poster session during lunch will provide a forum for data and hypothesis exchange.


Vegan lose weight fast tips The afternoon will be devoted to a discussion of mechanisms thought to play important roles in the syndrome/diseases and provide insight into drugs and environmental agents thought to influence them. Paleo diet smoothies Our focus on understanding the pathways and risk factors leading to disease and how these pathways can be perturbed to develop drugs for disease interventions creates a unique combination that is likely to lead to new thought processes and scientific collaborations in addition to defining knowledge gaps, identifying research needs, protecting public health, and empowering product development.

The specific objectives of this conference include the following:

• Provide a better understanding of metabolic syndrome and associated disease entities, their unifying factors, and mechanisms behind the pathology that could enable the development of safer drugs and understanding of problematic environmental toxicants. Exercise pictures funny Attendees will learn about this syndrome (probably many for the first time as most focus on one organ type), the role development plays, associated diseases, challenges in therapeutic strategies, and mechanisms behind their onset.

• Serve as a “melting pot” to expose individuals to a syndrome, its associated diseases, challenges in therapeutic interventions, role of toxicity of environmental chemicals or drugs, and mechanisms. Weight loss with yoga Since this meeting will address multiple aspects (bench to bedside), it can lead to new collaborations across these generally “siloed” domains with the goal of improving public health.

Attendees can book hotel rooms by using the SOT Housing website for the 2017 SOT Annual Meeting. Losing weight after menopause By using the SOT Housing Service, attendees receive discounted hotel room rates and personalized services not available via other methods. Low carb diet side effects headache Should you have a problem reserving your accommodations, please contact Jay Pierce at Connections Housing, 404.918.9129.

We welcome both junior and senior scientists to present and share their results. Best diet to lose weight quickly Please contact SOT Headquarters if you have any questions regarding the meeting abstracts.

Submit an Abstract (SOT Members are encouraged to log in to have the form pre-populate your contact information.)

The abstract submission system is open until 11:59 PM ET on March 1, 2017. Military diet before and after Additional information for speakers, graduate students, and postdoctoral scholars will be available at that time.

Keynote Lecture—Metabolic Diseases: Clinical Manifestations, Role of Genetics, and Lifestyles

Anna Mae Diehl, MD, Florence McAlister Professor of Medicine, Duke University, Durham, North Carolina

The keynote lecture will provide an overview of the metabolic syndrome and some of its causative modalities and end with a focus on liver damage.

Plenary Session I—Developmental Aspects Related to Metabolic Disease

Speakers will discuss the effects of metabolic dysfunction on normal development.

Chair: Kenneth L. Weight loss drugs Hastings, MPH, DrPH, Hastings Toxicology Consulting LLC, Mount Airy, Maryland

Lisa Swartz Topor, MD, MMSc, Alpert Medical School, Brown University, Providence, Rhode Island

Development of Neuroendocrine Systems Governing Energy Homeostasis

Sebastien Bouret, PhD, Keck School of Medicine, University of Southern California, Los Angeles, California

Plenary Session II—Diseases Associated with Metabolic Syndrome and Challenges in Therapeutic Strategies

Metabolic syndrome is associated with many pathologies and, in itself, is a “toxic” environment. Losing weight due to stress This session will focus on some examples of such diseases and challenges seen in drug development.

Chair: Thaddeus Schug, PhD, NIEHS, Research Triangle Park, North Carolina

Overview of Metabolic Syndrome Associated Obesity and Treatments

Robert E. Healthy diet lunch Ratner, MD, Georgetown University Medical Center, Washington, District of Columbia

Drug Development for Treatment of Diabetes: Experiences with Preclinical Tumor Findings for an SGLT2 Inhibitor

Mark D. Weight loss recipes vegetarian Johnson, PhD, Janssen Pharmaceutical Company, Raritan, New Jersey

Norman Stockbridge, MD, PhD, US Food and Drug Administration/Center for Drug Evauation and Research, Silver Spring, Maryland

The sessions above will acquaint the audience with some of the mechanisms behind these abnormalities, the similarity with environmental agents, and the influence of the microbiome.

Chair: Susan G. Exercise at home Emeigh Hart, VMD, PhD, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut

Mitochondrial Dysfunction and Metabolic Syndrome—Are Genetics, Drug, and Environmental Toxins Responsible?

Metaorganismal Endocrinology: Gut Microbial Metabolites as Postprandial Hormones Impacting Metabolic Disease Effects

Jonathan Mark Brown, Cleveland Clinic, Lerner Research Institute, Cleveland, Ohio

Environmental Agents and Drugs That May Affect Metabolic Syndrome and Associated Diseases

Michele La Merrill, PhD, University of California Davis, Davis, California

Carrie R. Exercise with chair Fleming, PhD, Dow AgroSciences, Indianapolis, Indiana

Florence Burleson, PhD, BRT Burleson Research Technologies, Inc., Morrisville, North Carolina

Fees include all general sessions, program materials, and refreshments throughout the course of the meeting.

Registration fees may be paid by check (please list all registrants on the check stub), money order, credit card (Visa, MasterCard, Diner’s Club, or American Express), or by a US Government Purchase Order (check must be drawn from the US Department of the Treasury). Weight loss eating plan pdf Please use the registration form. Military diet day 2 All wire transfers should include an additional $40 processing fee.

Note: For individuals who are not members of SOT, participation in SOT’s CCT—Metabolic Syndrome and Associated Diseases is available only to bona fide individuals who are engaged in or promote the field of toxicology or biotechnology research and support the growth and development of the toxicology field. Healthy diet plans for men For organizations, participation in the SOT’s CCT—Metabolic Syndrome and Associated Diseases is available only to bona fide organizations with public policy positions and business practices that are generally consistent with SOT’s mission, goals, reputation, and its policies and principles as determined by SOT. Paleo apple muffins SOT reserves the right to review applications for participation at SOT’s CCT—Metabolic Syndrome and Associated Diseases to confirm that the applicant meets these criteria and may, at the SOT’s sole discretion, reject a registration by an individual or business or withdraw registration privileges at any time if any individual or organization is found to be inconsistent with SOT’s principles and interests.

NOTE: To prevent double-billing, if you are registering by fax, DO NOT mail your original registration form. Lose belly fat women SOT needs only one copy for processing.

Registration Cancellation Refund Policy: All requests for cancellations and/or refunds must be received in writing to SOT Headquarters by February 10, 2017. 5 week diet plan These refunds will be processed, less a $30 fee, following the Meeting.

Disabled Attendees: If you need special assistance for this meeting, please contact SOT Headquarters at 703.438.3115.

SOT—Dedicated to Creating a Safer and Healthier World by Advancing the Science and Increasing the Impact of Toxicology.

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