Hfe gene – genetics home reference

The HFE gene provides instructions for producing a protein that is located on the surface of cells, primarily liver and intestinal cells. How to lose weight in a day for wrestling The HFE protein is also found on some immune system cells.

The HFE protein interacts with other proteins on the cell surface to detect the amount of iron in the body.


How do i lose belly fat at home The HFE protein regulates the production of another protein called hepcidin, which is considered the “master” iron regulatory hormone. Lose belly fat diet and exercise plan Hepcidin is produced by the liver, and it determines how much iron is absorbed from the diet and released from storage sites in the body. Paleo diet grocery list When the proteins involved in iron sensing and absorption are functioning properly, iron absorption is tightly regulated. Exercise is medicine On average, the body absorbs about 10 percent of the iron obtained from the diet.

The HFE protein also interacts with two proteins called transferrin receptors; however, the role of these interactions in iron regulation is unclear.

Researchers have identified more than 20 mutations in the HFE gene that cause a form of hereditary hemochromatosis called type 1. Healthy diet chart for indian Two particular mutations are responsible for most cases of this disorder. 5 exercises Each of these mutations changes one of the protein building blocks (amino acids) in the HFE protein. Paleo grubs One mutation replaces the amino acid cysteine with the amino acid tyrosine at position 282 in the protein’s chain of amino acids (written as Cys282Tyr or C282Y). How to lose belly fat fast naturally The other mutation replaces the amino acid histidine with the amino acid aspartic acid at position 63 (written as His63Asp or H63D).

The Cys282Tyr mutation prevents the altered HFE protein from reaching the cell surface, so it cannot interact with hepcidin and transferrin receptors. Paleo diet testimonials As a result, iron regulation is disrupted, and too much iron is absorbed from the diet. What should i weigh calculator This increase in the absorption of dietary iron leads to the iron overload characteristic of type 1 hemochromatosis.

Mutations in the HFE gene that cause hereditary hemochromatosis also increase the risk of developing the most common form of porphyria, porphyria cutanea tarda. Paleohacks cookbook review These mutations are found more frequently in people with porphyria cutanea tarda than in unaffected people.

Researchers suspect that HFE gene mutations may trigger this type of porphyria by increasing the absorption of iron. Exercises to burn fat in stomach A buildup of excess iron, in combination with other genetic and nongenetic factors, interferes with the production of a molecule called heme. Paleo energy balls Heme is a component of iron-containing proteins called hemoproteins, including hemoglobin (the protein that carries oxygen in the blood). Paleomg recipes A blockage in heme production allows other compounds called porphyrins to build up to toxic levels in the liver and other organs. Military diet snacks These compounds are formed during the normal process of heme production, but excess iron and other factors allow them to accumulate to toxic levels. How to lose weight in college The abnormal buildup of porphyrins leads to the characteristic features of porphyria cutanea tarda.

The Cys282Tyr mutation, which is a common cause of hereditary hemochromatosis, may also increase the severity of the iron overload in X-linked sideroblastic anemia when it is inherited with a mutation in the ALAS2 gene. Paleo hamburger The combination of HFE and ALAS2 mutations leads to more severe signs and symptoms of X-linked sideroblastic anemia by further increasing the absorption of dietary iron, leading to an even greater iron overload.

Egger NG, Goeger DE, Payne DA, Miskovsky EP, Weinman SA, Anderson KE. 2 week weight loss results Porphyria cutanea tarda: multiplicity of risk factors including HFE mutations, hepatitis C, and inherited uroporphyrinogen decarboxylase deficiency. Fastest way to lose weight for women Dig Dis Sci. How to lose weight really fast unhealthy 2002 Feb;47(2):419-26.

Kelleher T, Ryan E, Barrett S, Sweeney M, Byrnes V, O’Keane C, Crowe J. Exercise lower back pain Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis. Exercise calories burned walking Gut. Exercise at home for men 2004 Aug;53(8):1174-9.

Phillips JD, Bergonia HA, Reilly CA, Franklin MR, Kushner JP. How to lose weight properly A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda. Military diet recipe Proc Natl Acad Sci U S A. Lose belly fat quickly 2007 Mar 20;104(12):5079-84. Diet plan to lose weight fast at home Epub 2007 Mar 9.

Zaahl MG, Merryweather-Clarke AT, Kotze MJ, van der Merwe S, Warnich L, Robson KJ. Weight loss graph Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload. Exercise challenge team names Hum Genet. Best diet for women over 40 2004 Oct;115(5):409-17. Lose belly fat challenge Epub 2004 Aug 24.

The resources on this site should not be used as a substitute for professional medical care or advice. Weight loss team names for accountants Users with questions about a personal health condition should consult with a qualified healthcare professional.

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